Scientist

m/f/d, Basel Region

We are looking for a highly skilled and proactive expert in mouse genetics and colony management to support the generation, validation, and long-term quality oversight of sophisticated transgenic mouse models.

The ideal candidate combines strong technical expertise with operational excellence and a deep commitment to animal welfare. In this role, you will serve as a key interface between internal scientific stakeholders, external breeding partners, and CROs—ensuring that transgenic lines are generated, maintained, and characterized to the highest scientific and ethical standards.

This position plays a critical role in enabling reliable in vivo research and accelerating therapeutic innovation by translating genetic concepts into robust, well-characterized experimental cohorts.

Key Responsibilities

As part of the In Vivo Sciences team, you will:

Provide high-level oversight of external Contract Research Organizations (CROs) and internal breeding facilities to ensure high-quality delivery, operational performance, and compliance
Develop and implement optimized breeding strategies (quality, timelines, cost) to maintain genetic stability and minimize surplus animals, in alignment with the 3Rs (Replacement, Reduction, Refinement)
Serve as the primary point of contact for external vivarium managers, troubleshooting issues related to colony performance, phenotype drift, and health status
Act as the internal subject matter expert for the generation of new mouse lines using state-of-the-art technologies
Define and standardize official nomenclature for newly generated lines in accordance with MGI (Mouse Genome Informatics) and International Committee guidelines
Maintain accurate and complete records of genotypes and molecular validation data, including NGS, Southern Blot, and qPCR results
Monitor animal health and welfare across experimental cohorts, define humane endpoints, and oversee assessments of unexpected phenotypes in newly generated lines
Establish and implement standards for housing and care of contract-bred animals at external partners
Collaborate closely with therapeutic area scientists to support initial phenotypic characterization and confirm model suitability for research needs

Must-Have Qualifications & Experience

To be successful in this role, you bring:

PhD in Genetics, Molecular Biology, Biotechnology, or a related field ⭐
3+ years of hands-on experience in mouse genetics and colony management ⭐
Proven track record in generating mouse models (e.g., transgenic/knock-in/knock-out lines)
Strong project management capabilities, including the ability to manage multiple external vendors and partnerships
Solid understanding of regulatory and animal welfare requirements, including FELASA guidelines and relevant legislation ⭐
Excellent written and verbal communication skills in English (German is a strong plus)